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Current Evidence for the Benefits of Melatonin
Summarized from the Mayo Clinic.
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Alzheimer's Disease (sleep disorders) Extent of Studies: Limited Level of Evidence: Unclear Results: Unclear if beneficial Antioxidant (free radical scavenging) Extent of Studies: Over 100 laboratory and animal Level of Evidence: Unclear Results: Suggest the prevention or treatment of conditions associated with oxidative damage Attention Deficit Hyperactivity Disorder (ADHD) Extent of Studies: Limited Level of Evidence: Unclear Results: Unclear Benzodiazepine Tapering Extent of Studies: Small Level of Evidence: Unclear Results: Promising Bipolar Disorder (sleep disturbances) Extent of Studies: Limited Level of Evidence: Unclear Results: Unclear Cancer Treatment Extent of Studies: Several Level of Evidence: Unclear Results: Mixed, promising Chemotherapy Side Effects Extent of Studies: Several Level of Evidence: Unclear Results: Promising early results include reductions in nerve injury, mouth sores, wasting, and platelet count drops, heart and lung damage. Circadian Rhythm Entraining (in blind persons) Extent of Studies: Multiple Level of Evidence: Unclear Results: Suggest that melatonin, administered in the evening, may correct circadian rhythm. Delayed Sleep Phase Syndrome (DSPS) Extent of Studies: Several, Small Level of Evidence: Good Results: Promising. Depression (sleep disturbances) Extent of Studies: Limited Level of Evidence: Unclear Results: Limited Glaucoma Extent of Studies: Limited Level of Evidence: Unclear Results: Preliminary evidence that melatonin may actually decrease intraocular pressure in the eye Headache Prevention Extent of Studies: Several, small Level of Evidence: Unclear Results: Suggest possible benefits in all three types of headache High Blood Pressure (hypertension) Extent of Studies: Several, mostly small Level of Evidence: Unclear Results: Small reductions in diastolic and systolic blood pressure HIV / AIDS Extent of Studies: Lacking Level of Evidence: Unclear Results: Melatonin should not be used in place of more proven therapies, and patients with HIV/AIDS are advised to be treated under the supervision of a medical doctor.' Insomnia (of unknown origin in the non-elderly) Extent of Studies: Several, small Level of Evidence: Unclear Results: Inconsistent. Insomnia in the Elderly Extent of Studies: Several Level of Evidence: Good Results: Suggest short-term benefits. Jet Lag Extent of Studies: Several Level of Evidence: Strong Results: Strong evidence. Suggest benefits of melatonin in up to half of people taking melatonin. Parkinson's Disease Extent of Studies: Very limited Level of Evidence: Unclear Results: Unclear Periodic Limb Movement Disorder Extent of Studies: Very limited Level of Evidence: Unclear Results: Unclear Preoperative Sedation / Anxiolysis Extent of Studies: Small number Level of Evidence: Unclear Results: Promising REM Sleep Behavior Disorder Extent of Studies: Limited case reports Level of Evidence: Unclear Results: Some benefits Rett Syndrome (female children) Extent of Studies: Limited Level of Evidence: Unclear Results: Unclear Schizophrenia (sleep disorders) Extent of Studies: Limited Level of Evidence: Unclear Results: Unclear Seasonal Affective Disorder (SAD) Extent of Studies: Several, small Level of Evidence: Unclear Results: Not well reported Seizure Disorder (children) Extent of Studies: Several case studies, limited animal research Level of Evidence: Unclear Results: Controversial, suggests possible anti-seizure effects. However, melatonin may actually lower seizure threshold and increase the risk of seizures. Sleep Disturbances Due to Pineal Region Brain Damage Extent of Studies: Several Level of Evidence: Unclear Results: Improvements in sleep patterns in young people. Consideration of melatonin in such patients should be under the direction of a qualified healthcare provider. Sleep Disturbances in Children with Neuro-Psychiatric Disorders Extent of Studies: Multiple Level of Evidence: Good Results: Reduced time to fall asleep, increased sleep duration. Sleep Enhancement in Healthy People Extent of Studies: Multiple Level of Evidence: Good Results: Suggest decrease the time it takes to fall asleep, increases the feeling of 'sleepiness,' and may increase the duration of sleep. Sleep in Asthma Extent of Studies: Preliminary Level of Evidence: Unclear Results: Possible improvements Smoking Cessation Extent of Studies: Small Level of Evidence: Unclear Results: Promising in reducing symptoms associated with smoking cessation, such as anxiousness, restlessness, irritability, and cigarette craving. Stroke Extent of Studies: (none listed) Level of Evidence: Unclear Results: Unclear. Possible reduction of neurological damage and melatonin levels. Tardive Dyskinesia Extent of Studies: Limited, small Level of Evidence: Unclear Results: Mixed Thrombocytopenia (low platelets) Extent of Studies: Some cases studies Level of Evidence: Unclear Results: Unclear Ultraviolet Light Skin Damage Protection Extent of Studies: Several, small Level of Evidence: Unclear Results: Reductions in erythema (skin redness) Work Shift Sleep Disorder Extent of Studies: Several Level of Evidence: Unclear Results: Mixed |
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